CBMN : Institute of Chemistry & Biology of Membranes & Nano-objects

Focuses of research & scientific skills

• Biophysical Chemistry
  • Structure, dynamics and mode of action of peptides, proteins, lipids and nucleic acids.
  • Complex assemblies: model and natural membranes, colloidal and non-covalent complexes.
• Biomimetic and therapeutic chemistry
  • Organic synthesis of biologically active molecules
  • Synthesis of biomimetic supramolecular scaffolds.
  • Production of new drugs
  • Production of new biomimetic scaffolds Biology and biotechnology
• Biology and biotechnology
  • Cell adhesion
  • Vesicular transport
  • Membrane fusion
  • Probiotics
  • Colloids for healt
  • Nutrition
  • biomaterials

Specific equipment, resources and techniques

• Diffraction and diffusion of X-rays: Crystallochemistry from very small monocrystals (some microns), Structural Biology.
• Electron Microscopy: Deposition of small objects with or without negative staining, cell or tissue section, cryo-EM, tomography and cryo-tomography.
• Mass spectrometry: Lipidomics, structural analyzes, multiple Reaction Monitoring (MRM) quantification, ...
• Nuclear Magnetic Resonance: Structural and dynamic study of self-assembled molecules. NMR of membrane lipids, peptides and membrane proteins, natural colloids associated with oenological and pharmaceutical domains. Protein / RNA complex and protein-protein interactions. Structural and conformational studies of molecules, ...
• Atomic force microscopy: Surface properties (topography, nano mechanics) of soft or hard materials.
• L2 culture room: Culture of eukaryotic cells belonging to risk group 2.
• Vibrational spectroscopy: Pharmacology and cosmetics, Geology, Carbonaceous materials, Semiconductors, Life sciences, ...
• PLC Platform: Observation of nano-objects.
• Production and purification of recombinant proteins: recombinant protein production, purification by chromatography, isotopic labeling of proteins for NMR.