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Titanium Functionalized Bioactive Implants with Intelligent Antibiotic Systems

Domain Health and wellbeing

Technology Advanced and active materials

Applications

  • Preventionand/or treatment of prosthesis related infection in
  • Orthopedic joint replacement
  • Spine surgery

Challenges

Prosthesis related infection is a serious complication for patients, which is currently difficult to treat with classical antibiotic therapy Consequently, in most cases, removal of the infected prosthesis is the only solution to cure the infection.

Description

This project aims to develop orthopedic implants based on titanium functionalized with intelligent antibiotic systems Antibiotic release systems (widely used to prevent infections during orthopedic surgery are controlled by a change in pH on bone implants typically observed in bacterial infections.

Benefits

  • In site controlled delivery of antibiotics
  • Materials bifunctionalization with gentamicin and vancomycin
  • All titanium prosthesis could be coated
  • Hospital costs reduction
  • Extension to the local delivery of factors capable of regulating the relationship between an implant and the tissues surrounding it

Maturation

Maturation with Aquitaine Science Transfert showed the possibility of synthesizing bioactive implants allowing the release of an antibiotic only in case of infection

Inventors

Marie-Christine DURRIEU

Damien QUEMENER

Laboratoire de Chimie des Polymères
Organiques LCPO, UMR 5629)

 

Valérie HEROGUEZ

Hélène CARRIÉ

Loïc PICHAVANT

Institute of Chemistry and Biology
of Membranes and Nano objects
(CBMN, UMR 5248 )

IP

Patent applications WO 2016 097358 A 1 WO 2006 008386 A 1 WO 2006 008387 A 1

Contact

Carlos LARRAYA

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Jean Luc CHAGNAUD

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