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OLIGONUCLEOTID TABLETS: Process to formulate oligonucleotids into tablets for an oral administration

Domain Health and wellbeing

Technology Microfluidics

Applications

  • New galenic formulation for therapeutic approach based on oligonucleotids
  • Tablets suitable for siRNA, shRNA, miRNA, mRNA and RNAi
  • Oral administration of biological active molecules

Description

  • Patented process to compress into tablets the oligonucleotids while maintaining their therapeutic activity
  • Compatible with large panel of encapsulated vectors
  • Possibility to combine the approach with the well known process to control the delivery
  • Combination of multiple therapeutic oligonucleotids in a single tablet

Benefits

  • Opens new perspectives for simple use of therapeutic oligonucleotids
  • Obtention of sterilized, stable, easy to store tablets
  • High patient compliance expected

Inventors

Pierre TCHORELOFF

Virginie BUSIGNIES-GODDIN

Institut de Mécanique et d’Ingénierie de Bordeaux (I2M, UMR 5295)

Team: Galenics – Mechanics of Compacted Pharmaceutical Powders

 

Virginie ESCRIOU

Pascal BIGEY

Christine CHARRUEAU

Laboratory of “Chemical and Biological Technologies for Health” (Paris, UTCBS, UMR 8258, U 1022)

Contact

Jean-Luc CHAGNAUD

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